3-氧代四氢-1H-噁唑并[3,4-a]吡嗪-7(3H)-羧酸叔丁酯合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran Heating;
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran 2 h; Product distribution / selectivity;
参考文献
WO2007/146066 A2, ;
Page/Page column 70-71 ;
反应条件
1: 96 percent / triethylamine / methanol / 2 h / 50 °C 2: 85 percent / BH3*THF / tetrahydrofuran / 2 h / 50 °C 3: 17.6 g / NaH / tetrahydrofuran; various solvent(s) / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 14 p. 3057 - 3065
反应条件
1: 85 percent / BH3*THF / tetrahydrofuran / 2 h / 50 °C 2: 17.6 g / NaH / tetrahydrofuran; various solvent(s) / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 14 p. 3057 - 3065
反应条件
1: tert-butyl 3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate With sodium hydroxide in ethanol T=70°C; 1 h; 2: benzyl chloroformate in tetrahydrofuran; water 2 h;
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
反应条件
n-butyllithium in hexane Heating;
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
反应条件
sodium hydroxide in ethanol; water T=70°C; 1 h;
参考文献
CRITICAL THERAPEUTICS, INC.
Patent: WO2007/146066 A2, 2007 ;
Location in patent: Page/Page column 83 ;
