1-氮杂啶-3-基-二甲胺盐酸盐合成路线 （共 2 条）
反应条件
hydrogenchloride in diethyl ether
T=20°C; 0.666667 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
Location in patent: Page/Page column 94; 95 ;
WO 2013/014448 A1
反应条件
1.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 2 h / 100 °C
1.2: 2 h / 90 °C
2.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
3.1: hydrogenchloride / diethyl ether / 0.67 h / 20 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
