反应条件
1.1: imidazole / dimethylformamide / 12 h / 25 °C
2.1: I2; PDC / CH2Cl2 / 48 h / 25 °C
3.1: BH3*PhNEt2 / diphenyl((S)-pyrrolidin-2-yl)methanol; B(OMe)3 / tetrahydrofuran / 1.5 h / 25 °C
4.1: 91 percent / DMAP; pyridine / diethyl ether / 2 h / 25 °C
5.1: CuCN*2LiCl / tetrahydrofuran / 0.5 h / 0 °C
5.2: 66 percent / tetrahydrofuran / 25 °C
6.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C
6.2: B(OMe)3 / tetrahydrofuran; pentane / 24 h / -78 - 25 °C
6.3: 45 percent / NaBO3*4H2O / tetrahydrofuran; pentane / 24 h / 25 °C
7.1: p-TsOH / benzene / 12 h / 25 °C
8.1: TBAF / tetrahydrofuran / 16 h / 25 °C
9.1: 17 mg / Celite; CrO3 / diethyl ether; CH2Cl2 / 12 h / 25 °C
View Scheme
参考文献
Soorukram, Darunee; Knochel, Paul
Organic Letters, 2007 , vol. 9, # 6 p. 1021 - 1023
