3-氟-5-(5-((2-甲基噻唑-4-基)乙炔)吡啶-2-基)苯甲腈合成路线 (共 1 条)
反应条件
potassium carbonate; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether; water
T=20 - 80°C;
参考文献
Cosford, Nicholas D.; Seiders, Thomas J.; Payne, Joseph; Roppe, Jeffrey R.; Huang, Dehua; Smith, Nicholas D.; Poon, Steve F.; King, Chris; Eastman, Brian W.; Wang, Bowei; Arruda, Jeannie M.; Vernier, Jean-Michel; Zhao, Xiumin
Patent: US2009/203903 A1, 2009 ;
Location in patent: Page/Page column 9 ;
US 20090203903 A1