3-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-8-甲醛合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=-78 - 0°C;
2: With water; sodium hydrogencarbonate in tetrahydrofuran
参考文献
CHEMOCENTRYX, INC.
Patent: WO2007/51062 A2, 2007 ;
Location in patent: Page/Page column 138-139 ;
WO 2007/051062 A2
反应条件
hydrogenchloride; SnCl2·2H2O in tetrahydrofuran; water
参考文献
Giubellina, Nicola; Stabile, Paolo; Laval, Gilles; Perboni, Alcide D.; Cimarosti, Zadeo; Westerduin, Pieter; Cooke, Jason W. B.
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 859 - 867
反应条件
iron; ammonium chloride in water; N,N-dimethyl-formamide
T=20 - 100°C; 1.66667 h; Large scale reaction;
参考文献
Giubellina, Nicola; Stabile, Paolo; Laval, Gilles; Perboni, Alcide D.; Cimarosti, Zadeo; Westerduin, Pieter; Cooke, Jason W. B.
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 859 - 867
反应条件
1: N-ethyl-N,N-diisopropylamine / 2-methyl tetrahydrofuran / 0.5 h / 80 °C / Large scale reaction
2: iron; ammonium chloride / water; N,N-dimethyl-formamide / 1.67 h / 20 - 100 °C / Large scale reaction
View Scheme
参考文献
Giubellina, Nicola; Stabile, Paolo; Laval, Gilles; Perboni, Alcide D.; Cimarosti, Zadeo; Westerduin, Pieter; Cooke, Jason W. B.
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 859 - 867
反应条件
1: N-ethyl-N,N-diisopropylamine / 2-methyl tetrahydrofuran / 0.5 h / 80 °C / Large scale reaction
2: hydrogenchloride; SnCl2·2H2O / tetrahydrofuran; water
View Scheme
参考文献
Giubellina, Nicola; Stabile, Paolo; Laval, Gilles; Perboni, Alcide D.; Cimarosti, Zadeo; Westerduin, Pieter; Cooke, Jason W. B.
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 859 - 867
