(S)-1,2,3,4-四氢-5-甲氧基-N-丙基-2-萘胺盐酸盐合成路线 （共 10 条）
反应条件
hydrogenchloride in tetrahydrofuran; water T=65°C; 0.25 h;
参考文献
UCB PHARMA GMBH; Ates, Celal; Schule, Arnaud; Palacio, Magali; Deutsch, Paul; Vasselin, David; Carly, Nicolas; Phadtare, Ganesh; Yerande, Swapnil; Delatinne, Jean-Pierre; Escudero Hernandez, Maria Luisa; Pinilla, Veronique
Patent: US2013/102794 A1, 2013 ;
Location in patent: Paragraph 0233-0234 ;
反应条件
1: With sodium hydroxide in 2-methyl tetrahydrofuran; water T=20°C; 2: With hydrogenchloride in 2-methyl tetrahydrofuran; water T=60°C;
参考文献
UCB PHARMA GMBH; Ates, Celal; Schule, Arnaud; Palacio, Magali; Deutsch, Paul; Vasselin, David; Carly, Nicolas; Phadtare, Ganesh; Yerande, Swapnil; Delatinne, Jean-Pierre; Escudero Hernandez, Maria Luisa; Pinilla, Veronique
Patent: US2013/102794 A1, 2013 ;
Location in patent: Paragraph 0230-0232 ;
反应条件
hydrogenchloride in tetrahydrofuran; water T=70°C;
参考文献
WO2011/161255 A2, ;
Page/Page column 32 ;
反应条件
hydrogenchloride; palladium 10 on activated carbon; hydrogen in ethanol; water P=1810.07 Torr;
参考文献
Webster, Robert; Boyer, Alistair; Fleming, Matthew J.; Lautens, Mark
Organic Letters, 2010 , vol. 12, # 23 p. 5418 - 5421
反应条件
1.1: sodium acetate; acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 0 - 10 °C 1.2: 0.5 h / 0 - 20 °C 1.3: 1.33 h / 10 - 50 °C 2.1: potassium carbonate / 2-methyl tetrahydrofuran / Reflux 3.1: methyltretrahydrofuran, 2- / 75 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C View Scheme
反应条件
1: methyltretrahydrofuran, 2- / 75 °C 2: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C View Scheme
反应条件
1.1: lauryl mercaptan / ethyl acetate / Inert atmosphere; Reflux 1.2: 0.58 h / Inert atmosphere; Reflux 1.3: 0.08 h / Reflux 2.1: potassium carbonate / 2-methyl tetrahydrofuran / Reflux 3.1: methyltretrahydrofuran, 2- / 75 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C View Scheme
反应条件
1: potassium carbonate / 2-methyl tetrahydrofuran / Reflux 2: methyltretrahydrofuran, 2- / 75 °C 3: hydrogenchloride / water; tetrahydrofuran / 0.25 h / 65 °C View Scheme
反应条件
1.1: sodium hydrogensulfite; water; hydrogen bromide; acetic acid / 2 h / Reflux 2.1: sodium carbonate / o-xylene; water / 70 - 80 °C 2.2: Reflux 2.3: 15 - 55 °C 3.1: ammonia / cyclohexane; water / Reflux View Scheme
反应条件
1.1: sodium hydrogensulfite; water; hydrogen bromide; acetic acid / 2 h / Reflux 2.1: sodium carbonate / o-xylene; water / 70 - 80 °C 2.2: Reflux 2.3: 15 - 55 °C View Scheme
参考文献
UCB PHARMA GMBH; ATES, Celal; SCHULE, Arnaud; PALACIO, Magali; DEUTSCH, Paul; VASSELIN, David; CARLY, Nicolas; PHADTARE, Ganesh; YERANDE, Swapnil; DELATINNE, Jean-Pierre; ESCUDERO HERNANDEZ, Maria Luisa; PINILLA, Veronique
Patent: WO2011/161255 A2, 2011 ;
