1-(5-氯-2-苯并恶唑基)-4-哌啶羧酸合成路线 （共 4 条）
反应条件
1: chlorine / dichloromethane / 4 h / 0 - 20 °C
2: triethylamine / dichloromethane / 2 h / 20 °C
3: sodium hydroxide / methanol; water
View Scheme
参考文献
Kablaoui, Natasha; Patel, Snahel; Shao, Jay; Demian, Douglas; Hoffmaster, Keith; Berlioz, Francioise; Vazquez, Michael L.; Moore, William M.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 907 - 911
反应条件
1: triethylamine / dichloromethane / 2 h / 20 °C
2: sodium hydroxide / methanol; water
View Scheme
参考文献
Kablaoui, Natasha; Patel, Snahel; Shao, Jay; Demian, Douglas; Hoffmaster, Keith; Berlioz, Francioise; Vazquez, Michael L.; Moore, William M.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 907 - 911
反应条件
1: pyridine / |Reflux
2: chlorine / dichloromethane / 4 h / 0 - 20 °C
3: triethylamine / dichloromethane / 2 h / 20 °C
4: sodium hydroxide / methanol; water
View Scheme
参考文献
Kablaoui, Natasha; Patel, Snahel; Shao, Jay; Demian, Douglas; Hoffmaster, Keith; Berlioz, Francioise; Vazquez, Michael L.; Moore, William M.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 907 - 911
反应条件
sodium hydroxide in methanol; water
参考文献
Kablaoui, Natasha; Patel, Snahel; Shao, Jay; Demian, Douglas; Hoffmaster, Keith; Berlioz, Francioise; Vazquez, Michael L.; Moore, William M.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 907 - 911
