3-[(2-氯-5-甲基-4-嘧啶基)氨基]-N-(叔丁基)苯磺酰胺合成路线 (共 2 条)
反应条件
caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane 3 h; Heating / reflux;
参考文献
TARGEGEN, INC.; TEFFERI, Ayalew
Patent: WO2012/60847 A1, 2012 ;
Location in patent: Page/Page column 42 ;
反应条件
in methanol; water T=45°C; 20 h; Industry scaleInert atmosphere;
参考文献
TARGEGEN, INC.; TEFFERI, Ayalew
Patent: WO2012/60847 A1, 2012 ;
Location in patent: Page/Page column 42-43 ;