3,4-二氟-2-羟基苯甲醇合成路线 （共 4 条）
反应条件
1: 3,4-difluoro-2-hydroxybenzoic acid With BH3.MeS in tetrahydrofuran
T=30°C; 3.33333 h;
2: methanol in tetrahydrofuran
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/77009 A1, 2008 ;
Location in patent: Page/Page column 46 ;
WO 2008/077009 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
2: With hydrogenchloride in tetrahydrofuran; water
T=0 - 20°C; 0.166667 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/53082 A1, 2007 ;
Location in patent: Page/Page column 57-58 ;
WO 2007/053082 A1
反应条件
sodium metaborate tetrahydrate in water
T=40°C; 12 h; Green chemistry; regioselective reaction;
参考文献
Li, Hui-Jing; Wu, Ying-Ying; Wu, Qin-Xi; Wang, Rui; Dai, Chun-Yang; Shen, Zhi-Lun; Xie, Cheng-Long; Wu, Yan-Chao
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 19 p. 3100 - 3107
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane
T=-5 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/77009 A1, 2008 ;
Location in patent: Page/Page column 46 ;
WO 2008/077009 A1
