6-溴-3-碘-8-甲基磺酰基-咪唑并[1,2-a]吡嗪合成路线 （共 3 条）
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide
T=60°C; 6.5 h; Inert atmosphere;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; KOPPITZ, Marcus; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; PRECHTL, Stefan; NGUYEN, Duy; SCOTT, William
Patent: WO2011/113862 A1, 2011 ;
Location in patent: Page/Page column 55-56 ;
WO 2011/113862 A1
反应条件
1: methanol / 16 h / 23 °C / Inert atmosphere
2: N-iodo-succinimide / N,N-dimethyl-formamide / 6.5 h / 60 °C / Inert atmosphere
View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; KOPPITZ, Marcus; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; PRECHTL, Stefan; NGUYEN, Duy; SCOTT, William
Patent: WO2011/113862 A1, 2011 ;
WO 2011/113862 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=105°C;
参考文献
SCHERING CORPORATION
Patent: WO2008/156614 A2, 2008 ;
Location in patent: Page/Page column 72; 73 ;
WO 2008/156614 A2
