2 - （4 -溴苯基）-2- （羟甲基）丙烷-1,3-二醇合成路线 （共 5 条）
反应条件
1: carbonic acid diethyl ester; potassium hydroxide / ethanol / 4 h / 110 - 200 °C 2: Jones reagent / acetone / 5 h / 20 °C View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
potassium hydroxide; carbonic acid diethyl ester in ethanol T=110 - 200°C; 4 h;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0602 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=20 - 60°C; 2.33333 h;
2: With water in tetrahydrofuran
Cooling with ice;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0601 ;
参考文献
The Regents of the University of California; The North Carolina State University Zettacore, Inc.
Patent: US2007/108438 A1, 2007 ;
反应条件
1.1: sodium ethanolate / N,N-dimethyl-formamide / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.33 h / 20 - 60 °C
2.2: |Cooling with ice
View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
