(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸合成路线 （共 7 条）
反应条件
1: With palladium 10 on activated carbon; hydrogen in ethanol T=25°C; 5 h; 2: With hydrogenchloride; water pH=5 - 6;
参考文献
ZHEJIANG JIUZHOU PHARMACEAUTICAL CO., LTD.; Gao, Hongjun; Li, Min
Patent: US2013/12735 A1, 2013 ;
Location in patent: Paragraph 0067 ;
反应条件
sodium periodate; ruthenium(III) chloride*(x)H2O in acetonitrile T=12 - 20°C; 2 h;
参考文献
WO2010/122578 A2, ;
Page/Page column 59 ;
反应条件
trifluoroacetic acid in dichloromethane 6 h;
参考文献
US2012/16126 A1, ;
Page/Page column 7-8 ;
US 20120016126 A1
反应条件
1.1: 2 h / 25 °C / |Inert atmosphere 2.1: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 25 °C 2.2: pH 5 - 6 View Scheme
反应条件
1.1: magnesium; iodine / tetrahydrofuran / 3 h / 25 °C / |Inert atmosphere 2.1: 2 h / 25 °C / |Inert atmosphere 3.1: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 25 °C 3.2: pH 5 - 6 View Scheme
反应条件
triethylamine in 1,4-dioxane; water T=20°C;
参考文献
Zhu, Yanyun; Xia, Shuang; Zhu, Mingjie; Yi, Weiyin; Cheng, Jiagao; Song, Gonghua; Li, Zhong; Lu, Peng
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 4953 - 4962
反应条件
hydrogenchloride in ethanol
optical yield given as percent ee;
参考文献
Tasnadi, Gabor; Forro, Enik; Fueloep, Ferenc
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 4 p. 793 - 799
