1-(苯并呋喃-5-基)环丙烷甲酸合成路线 （共 4 条）
反应条件
1: methanol; ethyl acetate
2: EtSH / AlCl3 / dichloromethane
3: sodium hydride / N,N-dimethyl-formamide; mineral oil
4: (+)-Norephedrine / anhydrous xylene
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: EtSH / AlCl3 / dichloromethane
2: sodium hydride / N,N-dimethyl-formamide; mineral oil
3: (+)-Norephedrine / anhydrous xylene
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide; mineral oil
2: (+)-Norephedrine / anhydrous xylene
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
hydrogen; platinum(IV) oxide in methanol
T=10 - 20°C; P=760.051 Torr; 72 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/141119 A2, 2008 ;
Location in patent: Page/Page column 71-72 ;
WO 2008/141119 A2
