2-叔丁基-4-碘-1-甲基-1H-咪唑合成路线 （共 4 条）
反应条件
1: With ethylmagnesium bromide in tetrahydrofuran; diethyl ether
T=0°C; 1 h; Inert atmosphere;
2: With water in tetrahydrofuran; diethyl ether
T=20°C; Inert atmosphere;
参考文献
Kunz, Peter C.; Thiel, Indre; Noffke, Anna Louisa; Reiss, Guido J.; Mohr, Fabian; Spingler, Bernhard
Journal of Organometallic Chemistry, 2012 , vol. 697, # 1 p. 33 - 40
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Kunz, Peter C.; Thiel, Indre; Noffke, Anna Louisa; Reiss, Guido J.; Mohr, Fabian; Spingler, Bernhard
Journal of Organometallic Chemistry, 2012 , vol. 697, # 1 p. 33 - 40
反应条件
1.1: iodine; potassium iodide; sodium hydroxide / water / 20 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Kunz, Peter C.; Thiel, Indre; Noffke, Anna Louisa; Reiss, Guido J.; Mohr, Fabian; Spingler, Bernhard
Journal of Organometallic Chemistry, 2012 , vol. 697, # 1 p. 33 - 40
反应条件
1: 1-methyl-4-iodo-2-tert-butylimidazole With ethylmagnesium bromide in diethyl ether; dichloromethane
T=20°C; 1 h;
2: trimethylstannyl chloride in diethyl ether; dichloromethane
T=20°C; 16.0833 h;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/56143 A2, 2007 ;
Location in patent: Page/Page column 62 ;
