6-氯-吡啶并[3,2-d]嘧啶-2,4-二胺合成路线 （共 8 条）
反应条件
1: in dimethylsulfon
T=165°C; 0.5 h;
2: With sodium hydroxide in dimethylsulfon; water
T=20°C; pH=9 - 10;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 99; 1/6; 4/6 ;
反应条件
1: NMP / 180 °C
2: Fe, HCl / methanol
3: dimethylsulfoxide
View Scheme
参考文献
Gangjee, Aleem; Zhu, Yuanming; Queener, Sherry F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4533 - 4541
反应条件
1: Fe, HCl / methanol
2: dimethylsulfoxide
View Scheme
参考文献
Gangjee, Aleem; Zhu, Yuanming; Queener, Sherry F.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4533 - 4541
反应条件
1: With hydrogenchloride; water
5 h; Heating / reflux;
2: With sodium hydroxide in water
pH=9 - 10; Product distribution / selectivity;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 48; 1/6; 4/6 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
2.75 h; Heating / reflux;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 65-66 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
4.25 h; Heating / reflux;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 66 ;
反应条件
1: 83 percent / various solvent(s) / 1 h / 195 °C
2: 72 percent / Bromine complex of 1,4-diazabicyclo<2.2.2>octane / aq. acetic acid / 19 h / Ambient temperature
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
反应条件
1: 50 percent / various solvent(s) / 1 h / 195 °C
2: 59 percent / Bromine complex of 1,4-diazabicyclo<2.2.2>octane / aq. acetic acid / 19 h / Ambient temperature
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
