4-[6-(5-甲酰基-噻唑-2-基氨基)-2-甲基-嘧啶-4-基]-哌嗪-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
7 h; Heating / reflux;
参考文献
TARGEGEN, INC.
Patent: WO2007/56023 A2, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/056023 A2
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane
0.333333 h;
2: 4-[6-(5-formyl-thiazol-2-ylamino)-2-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; hexane
16 h;
参考文献
TARGEGEN, INC.
Patent: WO2007/56023 A2, 2007 ;
Location in patent: Page/Page column 49-50 ;
WO 2007/056023 A2
