1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane 0.333333 h; 2: 4-[6-(5-formyl-thiazol-2-ylamino)-2-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; hexane 16 h;