反应条件
1.1: tetrahydrofuran / -65 - -45 °C / Industry scale 1.2: 10 °C / Industry scale; Inert atmosphere 2.1: ammonia / isopropyl alcohol; water / 18 h / 75 - 85 °C / Sealed vessel; Industry scale 3.1: caesium carbonate / triphenylphosphine / N,N-dimethyl-formamide; water / 95 - 105 °C / Industry scale; Inert atmosphere 3.2: Industry scale; Inert atmosphere View Scheme
参考文献
OSI PHARMACEUTICALS, LLC; CASTELHANO, Arlindo, L.; CUTTING, Gary, A.; LOCKE, Andrew, J.; MAO, Yunyu; MULVIHILL, Kristen, Michelle; NORRIE, Robert; O'BRIEN, Andrew, J.; PARK, Stuart, R.; RECHKA, Josef, A.; STEVENS, Andrew, Michael; THOMAS, Christopher, I.
Patent: WO2012/16095 A1, 2012 ;
