5-氰基-1H-吡咯-2-羧酸甲酯合成路线 （共 5 条）
反应条件
titanium(III) chloride in methanol; water
T=70°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/26149 A1, 2005 ;
Location in patent: Page/Page column 108 ;
WO 2005/026149 A1
反应条件
in N,N-dimethyl-formamide; acetonitrile
T=-40 - 20°C; 24 h;
参考文献
Pinter, Thomas; Simhadri, Chakravarthi; Hof, Fraser
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 4642 - 4648
反应条件
N,N-dimethyl-formamide
1.) acetonitrile, ice bath, 5 min, room temp., overnight; 2.) ice bath then 50 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Loader, Charles E.; Anderson, Hugh J.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2673 - 2676
反应条件
in N,N-dimethyl-formamide; acetonitrile
Overall yield = 35 percent;
参考文献
Chen, Jianyang; Peng, Haixia; He, Jinxue; Huan, Xiajuan; Miao, Zehong; Yang, Chunhao
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2669 - 2673
反应条件
lithium hydroxide hydrate in ethanol; water
2 h; Reflux;
参考文献
Pinter, Thomas; Simhadri, Chakravarthi; Hof, Fraser
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 4642 - 4648
