2-(5-苯基-2H-四唑-2-基)乙醇合成路线 （共 6 条）
反应条件
1: 45 percent / triethylamine / CHCl3 / 17 h / Heating 2: 77 percent / DBU / tetrahydrofuran / 1 h / Heating 3: 79 percent / 1,2-dichloro-benzene / 2 h / Heating View Scheme
参考文献
Moody, Christopher J.; Rees, Charles W.; Young, Richard G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 2 p. 329 - 333
反应条件
sodium hydroxide in ethanol
4 h; Ambient temperature;
参考文献
Buzilova, S. R.; Kuznetsova, N. I.; Shul'gina, V. M.; Gareev, G. A.; Vereshchagin, L. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 107 - 109
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 119 - 121
反应条件
1: 26 percent / methyltriphenylphosphonium iodide / hexamethylphosphoric acid triamide / 10 h
2: sodium ethoxide / ethanol / 0.75 h
3: 1.) tri-n-butylstannyl oxide / 1.) ethanol, reflux, 2 h, 2.) ether, 3 d, RT
View Scheme
参考文献
Casey, Michael; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1933 - 1941
反应条件
1: sodium ethoxide / ethanol / 0.75 h
2: 1.) tri-n-butylstannyl oxide / 1.) ethanol, reflux, 2 h, 2.) ether, 3 d, RT
View Scheme
参考文献
Casey, Michael; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1933 - 1941
反应条件
potassium hydroxide
1.) 1-propanol, 80 deg C, 1 h, 2.) 1-propanol, reflux, 1 d; Yield given. Multistep reaction;
参考文献
Lebreton, Luc; Curet, Olivier; Gueddari, Salach; Mazouz, Fathi; Bernard, Suzanne; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4786 - 4792
反应条件
tert.-butyl lithium
multistep reaction, generation and reaction of 2-lithioalkyl-5-phenyltetrazoles with electrophile;
参考文献
Moody, Christopher J.; Rees, Charles W.; Young, Richard G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 2 p. 323 - 327
