2-乙酰基-5-氯-1,2,3,4-四氢异喹啉合成路线 （共 5 条）
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Bojarski, Andrzej J; Mokrosz, Maria J; Minol, Sijka Charakchieva; Koziol, Aneta; Wesolowska, Anna; Tatarczynska, Ewa; Klodzinska, Aleksandra; Chojnacka-Wojcik, Ewa
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 87 - 95
反应条件
sulfuric acid; acetic acid in ethanol
T=20°C;
参考文献
Bojarski, Andrzej J; Mokrosz, Maria J; Minol, Sijka Charakchieva; Koziol, Aneta; Wesolowska, Anna; Tatarczynska, Ewa; Klodzinska, Aleksandra; Chojnacka-Wojcik, Ewa
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 87 - 95
反应条件
1: H2SO4; AcOH / ethanol / 20 °C
View Scheme
参考文献
Bojarski, Andrzej J; Mokrosz, Maria J; Minol, Sijka Charakchieva; Koziol, Aneta; Wesolowska, Anna; Tatarczynska, Ewa; Klodzinska, Aleksandra; Chojnacka-Wojcik, Ewa
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 87 - 95
反应条件
1: LiAlH4 / diethyl ether / Heating
2: H2SO4; AcOH / ethanol / 20 °C
View Scheme
参考文献
Bojarski, Andrzej J; Mokrosz, Maria J; Minol, Sijka Charakchieva; Koziol, Aneta; Wesolowska, Anna; Tatarczynska, Ewa; Klodzinska, Aleksandra; Chojnacka-Wojcik, Ewa
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 87 - 95
反应条件
potassium acetate; tri-cyclo-hexyl-phosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in ethylene glycol dimethyl ether
T=20 - 150°C; 2.5 h; Microwave;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/58602 A2, 2007 ;
Location in patent: Page/Page column 112-113 ;
WO 2007/058602 A2
