(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯合成路线 （共 8 条）
反应条件
sodium hydrogencarbonate in water; toluene T=20°C; 0.333333 - 0.666667 h; Product distribution / selectivity;
参考文献
WO2005/121084 A1, ;
Page/Page column 4-6 ;
反应条件
sodium hydroxide in dichloromethane; water T=0 - 3°C; 0.25 - 1 h; Product distribution / selectivity;
参考文献
US2007/232680 A1, ;
Page/Page column 11 ;
反应条件
(S)-α-hydroxybenzeneacetic acid in ethyl acetate T=0 - 5°C; 2 h; chiral resolution;
参考文献
Synthetic Communications, , vol. 38, # 11 p. 1737 - 1744
反应条件
hydrogenchloride in dichloromethane; water T=0 - 3°C; 2 - 3 h; Product distribution / selectivity;
参考文献
Bolugoddu, Vijayabhaskar; Mamilla, Srinivas Reddy; Golla, Chinamala Kondaiah; Madduri, Srinivasa Reddy; Kodipyaka, Ravinder; Das, Surajit; Bhushan, Indu; Mohan, Mailatur Sivaraman
Patent: US2007/232680 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
(S)-α-hydroxybenzeneacetic acid in ethyl acetate T=0 - 5°C; 2 h; chiral resolution;
参考文献
Malakondaiah, Golla China; Gurav; Reddy, Lekkala Amarnath; Babu, Karrothu Srihari; Bhaskar, Bolugoddu Vijaya; Reddy, Padi Pratap; Bhattacharya, Apurba; Anand, Ramasamy Vijaya
Synthetic Communications, 2008 , vol. 38, # 11 p. 1737 - 1744
反应条件
hydrogenchloride in dichloromethane; water T=0 - 3°C; 2 - 3 h; Product distribution / selectivity;
参考文献
Bolugoddu, Vijayabhaskar; Mamilla, Srinivas Reddy; Golla, Chinamala Kondaiah; Madduri, Srinivasa Reddy; Kodipyaka, Ravinder; Das, Surajit; Bhushan, Indu; Mohan, Mailatur Sivaraman
Patent: US2007/232680 A1, 2007 ;
Location in patent: Page/Page column 11 ;
参考文献
DSM IP ASSETS B.V.
Patent: WO2009/62999 A1, 2009 ;
Location in patent: Page/Page column 7-8 ;
反应条件
triethylamine in dichloromethane T=-15 - -10°C; 4 h;
参考文献
Singh, Girij Pal; Godbole, Himanshu M.; Nehate, Sagar P.; Mahajan, Pravin R.
Synthetic Communications, 2005 , vol. 35, # 2 p. 243 - 248
