2,2,2-三甲基苯乙酮合成路线 （共 203 条）
反应条件
1: HCONH2, HCO2H / 180 °C
2: benzene
View Scheme
参考文献
Cervinka,O.; Fusek,J.
Collection of Czechoslovak Chemical Communications, 1973 , vol. 38, p. 441 - 446
反应条件
formic acid
Leuckart reductive amination; 1 h; Heating;
参考文献
Dalmolen, Jan; Tiemersma-Wegman, Theodora D.; Nieuwenhuijzen, Jose W.; Van Der Sluis, Marcel; Van Echten, Erik; Vries, Ton R.; Kaptein, Bernard; Broxterman, Quirinius B.; Kellogg, Richard M.
Chemistry - A European Journal, 2005 , vol. 11, # 19 p. 5619 - 5624
反应条件
phosphoric acid; silica gel
T=360°C;
参考文献
Juge,F.E.; Fry,A.
Journal of Organic Chemistry, 1970 , vol. 35, # 6 p. 1876 - 1881
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran
T=0°C; 0.0833333 h;
2: 2,2-dimethylpropiophenone in tetrahydrofuran
T=20°C; 23 h;
3: With hydrogenchloride in tetrahydrofuran; water
pH=5;
参考文献
Bert, Katrien; Noel, Timothy; Kimpe, Wim; Goeman, Jan L.; Van Der Eycken, Johan
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 42 p. 8539 - 8550
反应条件
in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Pine, Stanley H.; Pettit, Robert J.; Geib, Gregory D.; Cruz, Susana G.; Gallego, Claudio H.; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1212 - 1216
反应条件
in diethyl ether
20 h; Heating;
参考文献
Andersson, Sven; Drakenberg, Torbjoern
Organic Magnetic Resonance, 1983 , vol. 21, # 12 p. 730 - 744
反应条件
sodium methylate in N,N,N',N',N'',N''-hexamethylphosphoric triamide
参考文献
Sakurai,H. et al.
Tetrahedron Letters, 1973 , p. 4193 - 4196
反应条件
n-butyllithium; diisopropylamine
1) THF, hexane, 2 h, r.t.; Yield given. Multistep reaction;
参考文献
Baciocchi, Enrico; Ruzziconi, Renzo
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4772 - 4778
反应条件
sodium hydroxide
1) THF, benzene or toluene a) 0 deg C to r.t. b) 15 min, r.t. 2) Et2O; Yield given. Multistep reaction;
参考文献
Pine; Shen; Hoang
Synthesis, 1991 , # 2 p. 165 - 167
反应条件
aluminium trichloride; zinc in acetonitrile
T=70°C; 20 h;
参考文献
Grant, Anya A.; Allukian, Myron; Fry, Albert J.
Tetrahedron Letters, 2002 , vol. 43, # 24 p. 4391 - 4393
