2,2,2-三甲基苯乙酮合成路线 （共 203 条）
参考文献
Skell; Hauser
Journal of the American Chemical Society, 1942 , vol. 64, p. 2633
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Ford; Thompson; Marvel
Journal of the American Chemical Society, 1935 , vol. 57, p. 2619,2621
反应条件
sodium amide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
参考文献
Bertsch,K. et al.
Chemische Berichte, 1977 , vol. 110, p. 3304 - 3313
反应条件
diethyl ether
optically inactive compound of mp: 140 degree Celsius;
参考文献
Jasiobedzki
Roczniki Chemii, 1959 , vol. 33, p. 321,329
Chem.Abstr., 1959 , p. 17967
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Bohlmann; Kieslich
Chemische Berichte, 1955 , vol. 88, p. 1211,1216
反应条件
potassium hydroxide; benzene
optically inactive compound of mp: 177 degree Celsius;
参考文献
Jasiobedzki
Roczniki Chemii, 1959 , vol. 33, p. 321,329
Chem.Abstr., 1959 , p. 17967
反应条件
2: aq. HBr / acetic acid
View Scheme
参考文献
Jasiobedzki,W. et al.
Roczniki Chemii, 1976 , vol. 50, p. 1301 - 1312
反应条件
N-bromosuccinmide; silver hexafluoroantimonate; [{(η5-C5Me5)RhCl}2(μ-Cl)2]; 2,2,2-trimethylacetic acid in 1,2-dichloro-ethane
T=120°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Schroeder, Nils; Wencel-Delord, Joanna; Glorius, Frank
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8298 - 8301
反应条件
dipotassium peroxodisulfate; N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate in 1,2-dichloro-ethane
T=80°C; 8 h; Sealed tube; regioselective reaction;
参考文献
Sun, Xiuyun; Shan, Gang; Sun, Yonghui; Rao, Yu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 16 p. 4440 - 4444
Angew. Chem., 2013 , vol. 125, # 16 p. 4536 - 4540,5
反应条件
nitric acid
T=25°C; 1.5 h; addition of sulfuric acid, other temperatures and time; Product distribution;
参考文献
Barker, Steven D.; Norris, Robert K.; Randles, David
Australian Journal of Chemistry, 1981 , vol. 34, # 9 p. 1875 - 1878
反应条件
2: (i) ZnI2, (ii) aq. NH4Cl, (iii) POCl3, Py
3: (i) iBu2AlH, (ii) aq. HCl
4: (i) nBuLi, (ii) /BRN= 2333617/
View Scheme
参考文献
Zimmerman,H.E.; Aasen,S.M.
Journal of Organic Chemistry, 1978 , vol. 43, # 8 p. 1493 - 1506
反应条件
hydrogenchloride; hydrogen sulfide in methanol
T=-0.1°C; 30 h;
参考文献
Klages, Claus-Peter; Voss, Juergen
Chemische Berichte, 1980 , vol. 113, # 6 p. 2255 - 2277
