2,4,6-三甲基苯甲酰氯合成路线 （共 72 条）
反应条件
in 1,2-dichloro-benzene
T=180°C; 2 h; Inert atmosphere;
参考文献
Lo Fiego, Marcos J.; Silbestri, Gustavo F.; Chopa, Alicia B.; Lockhart, Maria T.
Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1707 - 1714
参考文献
Fuson; Gaertner
Journal of Organic Chemistry, 1948 , vol. 13, p. 496,499
反应条件
in tetrahydrofuran; ethanol
inert atmosphere; -40°C (15 min), then stirring (20°C, 3 h); hydrolysis (aq. NaHCO3), extn., drying, concentration (vac.), distn. (vac.); elem. anal.;
参考文献
Castel; Riviere; Satge; Ko
Organometallics, 1990 , vol. 9, # 1 p. 205 - 210
反应条件
in tetrahydrofuran; diethyl ether
inert atmosphere; -78°C (40 min), then stirring (20°C, 3 h); hydrolysis (aq. NaHCO3), extn., drying (Na2SO4), concentration (vac.); NMR and GC/MS spectroscopy;
参考文献
Castel; Riviere; Satge; Ko
Organometallics, 1990 , vol. 9, # 1 p. 205 - 210
反应条件
1: LiAlH4; diethyl ether
2: hydrogen; CO; benzene / 190 °C / Reagens 4: Octacarbonyldikobalt; Reagens 5: CoCO3
View Scheme
参考文献
Wender et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4079,4082
参考文献
Fuson; Bottorff; Speck
Journal of the American Chemical Society, 1942 , vol. 64, p. 1450
Journal of the American Chemical Society, 1944 , vol. 66, p. 2135
反应条件
copper
1) THF, 25 deg C, 10 min, 2a) 25 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Ebert, Greg W.; Pfennig, Deborah R.; Suchan, Scott D.; Donovan, Thomas A.; Aouad, Emmanuel; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 8 p. 2361 - 2364
反应条件
in ethanol
T=20°C; 24 h; Inert atmosphere;
参考文献
Zhang, Ming
Journal of Chemical Research, 2013 , vol. 37, # 10 p. 606 - 610
参考文献
Valkevich, Ellen M.; Guenette, Robert G.; Sanchez, Nicholas A.; Chen, Yi-Chen; Ge, Ying; Strieter, Eric R.
Journal of the American Chemical Society, 2012 , vol. 134, # 16 p. 6916 - 6919
参考文献
Schiess,P.; Heitzmann,M.
Angewandte Chemie, 1977 , vol. 89, # 7 p. 485
