(R)-(-)-2-苯基丁酸合成路线 （共 45 条）
反应条件
sulfuric acid in 1,4-dioxane Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 116, # 20 p. 9361 - 9362
反应条件
4-(N,N-dimethlyamino)pyridine in pyridine T=20°C; 20 h;
参考文献
Journal of the American Chemical Society, , vol. 132, # 25 p. 8532 - 8533
反应条件
1: 88 percent 2: 92 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 0 °C 3: aq. 18 N H2SO4 / dioxane / 1.5 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 28 p. 6496 - 6511
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile 6 h;
参考文献
Journal of the American Chemical Society, , vol. 130, # 11 p. 3302 - 3303
反应条件
1: With n-butyllithium; diethylzinc; (S)-(+)-3-hydroxy-tetrahydrofuran in hexane; toluene T=-78 - 0°C; 13 h; 2: With hydrogenchloride in tetrahydrofuran T=20°C; 48 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 34 p. 5985 - 5987
反应条件
(S)-HBTM; N-ethyl-N,N-diisopropylamine in toluene T=0°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 14-15 p. 2301 - 2304
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 147.5 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 2 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
ruthenium trichloride; sodium periodate; diazomethyl-trimethyl-silane 1.) hexane, ether, MeOH, RT, 0.5 h, 2.) MeCN, CCl4, H2O, RT, 2 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Asymmetry, , vol. 2, # 7 p. 481 - 494
反应条件
Candida antarctica lipase A Phe149Tyr/Ile150Asn/Phe233Gly in acetonitrile T=20°C; 0.0333333 h; aq. phosphate bufferaq. bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 20 p. 7038 - 7042
