(R)-(-)-2-苯基丁酸合成路线 （共 45 条）
反应条件
Candida antarctica lipase A wild type in acetonitrile T=20°C; 4 h; aq. phosphate bufferaq. bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 20 p. 7038 - 7042
反应条件
hydrogen cation 7 h; Heating; Title compound not separated from byproducts;
参考文献
Beard, Timothy; Cohen, Mark A.; Parratt, Julian S.; Turner, Nicholas J.; Crosby, John; Moilliet, Jock
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1085 - 1104
反应条件
Palomo reagent; triethylamine in toluene 48 h; Ambient temperature; Yields of byproduct given;
参考文献
Mazon, Angel; Najera, Carmen; Yus, Miguel; Heumann, Andreas
Tetrahedron: Asymmetry, 1992 , vol. 3, # 11 p. 1455 - 1466
反应条件
1: Et3N; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 24 h / 20 °C 2: hydrobromic acid / acetic acid / 1 h / 100 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 3 p. 555 - 563
反应条件
1: Candida antarctica lipase B RG401 mutant; water / aq. phosphate buffer; acetonitrile / 4.5 h / 30 °C / pH 7.5 / |Resolution of racemate; |Enzymatic reaction 2: Candida antarctica lipase B RG401 mutant; water / aq. phosphate buffer / 25 °C / pH 7.5 / |Enzymatic reaction View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 5 p. 1872 - 1881
反应条件
sodium hydroxide in water 2 h; Ambient temperaturehorse liver esterase, pH 7.2; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 30, # 50 p. 7053 - 7056
反应条件
1: 31 percent / 71 h / 30 °C / Rhodococcus sp. (SP 361), pH 7 2: 54 percent / H+ / 7 h / Heating View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 6 p. 1085 - 1104
反应条件
1: 20 percent / 145 h / 30 °C / Rhodococcus sp. (SP 361), pH 7 2: 54 percent / H+ / 7 h / Heating View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 6 p. 1085 - 1104
反应条件
horse liver esterase; phosphoric buffer Ambient temperature; Yield given;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 2 p. 259 - 269
反应条件
1: With pyridine T=20°C; 20 h; 2: With sodium hydrogencarbonate T=20°C; 1 h; 3: With hydrogenchloride Further stages.;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 3 p. 379 - 383
