(R)-(-)-2-苯基丁酸合成路线 （共 45 条）
反应条件
Pseudomonas aeruginosa lipase Met16Ala/Leu17Phe/Leu162Asn mutant T=25°C; pH=7.5; aq. phosphate bufferEnzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Journal of the American Chemical Society, , vol. 132, # 26 p. 9144 - 9152
反应条件
n-butyllithium; (2,2-Me2-propyl)-((R)-1-phenyl-2-piperidin-1-yl-ethyl)-amine 1.) hexane, THF, 0 deg C, 15 min, 2.) hexane, THF, -78 deg C, 20 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 12 p. 2122 - 2124
反应条件
4-(N,N-dimethlyamino)pyridine in pyridine T=60°C; 4 h; study of racemization of acid chloride; Product distribution;
参考文献
Tetrahedron Letters, , vol. 30, # 28 p. 3629 - 3632
反应条件
4-(N,N-dimethlyamino)pyridine in pyridine T=60°C; 4 h; reaction with futher chiral alcohols for determination of their absolute configuration; Product distribution;
参考文献
Tetrahedron Letters, , vol. 30, # 28 p. 3629 - 3632
反应条件
(R)-1-phenylethan-1-ol in pyridine 20 h; Ambient temperatureoptical yield: 74.5percent; Yield given;
参考文献
Tetrahedron Letters, , vol. 30, # 28 p. 3629 - 3632
参考文献
Phytochemistry (Elsevier), , vol. 34, # 2 p. 467 - 472
参考文献
Helvetica Chimica Acta, , vol. 41, p. 1512,1514
Bulletin de la Societe Chimique de France, , p. 461,463
反应条件
216 h; SP361 enzyme system; Yield given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 3, # 12 p. 1543 - 1546
反应条件
sodium hydroxide; sodium phosphate buffer T=40°C; 1 h; lipase B from Candida antarctica presence, other arylaliphatic carboxylic acids vinyl and ethyl esters, other reaction time; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 64, # 2-5 p. 1709 - 1712
参考文献
Helvetica Chimica Acta, , vol. 41, p. 1512,1514
