2 - （1 -甲基- 1H -5-吡唑基）吡啶合成路线 （共 3 条）
反应条件
1: 5-iodo-1-methylpyrazole With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 2 h;
2: With indium(III) chloride in tetrahydrofuran; pentane
T=-78 - 20°C;
3: 2-iodo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; pentane
Heating; Further stages.;
参考文献
Font-Sanchis, Enrique; Cespedes-Guirao, F. Javier; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3589 - 3591
反应条件
in ethanol
T=60°C; 0.5 h;
参考文献
Uber, Jorge Salinas; Vogels, Yorick; Van Den Helder, Dave; Mutikainen, Ilpo; Turpeinen, Urho; Fu, Wen Tian; Roubeau, Olivier; Gamez, Patrick; Reedijk, Jan
European Journal of Inorganic Chemistry, 2007 , # 26 p. 4197 - 4206
反应条件
in V methoxymethyl ester
6 h; Inert atmosphereReflux;
参考文献
Comes Franchini, Mauro; Bonini, Bianca Flavia; Camaggi, Carlo Maurizio; Gentili, Denis; Pession, Annalisa; Rani, Monica; Strocchi, Elena
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2024 - 2033
