3-(1,3-二氧代丁基)恶唑烷-2-酮合成路线 （共 5 条）
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; acetyl chloride With pyridine
Inert atmosphere;
2: oxazolidin-2-one in toluene
8 h; Inert atmosphereReflux;
参考文献
Jacobine, Alexander M.; Puchlopek, Angela L.A.; Zercher, Charles K.; Briggs, Jon B.; Jasinski, Jerry P.; Butcher, Raymond J.
Tetrahedron, 2012 , vol. 68, # 38 p. 7799 - 7805
反应条件
1: oxazolidin-2-one With n-butyllithium in tetrahydrofuran; hexane
T=-78 - -40°C;
2: 4-methylene-oxetan-2-one in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Elsner, Petteri; Jiang, Hao; Nielsen, Johanne B.; Pasi, Filippo; Jorgensen, Karl Anker
Chemical Communications, 2008 , # 44 p. 5827 - 5829
反应条件
potassium fluoride; tetrabutyl-ammonium chloride in acetonitrile
Heating;
参考文献
Singh, Harjit; Kumar, Subodh
Journal of Chemical Research, Miniprint, 1987 , # 12 p. 3201 - 3213
反应条件
in toluene
3 h; Inert atmosphereHeating;
参考文献
Rossbach, Jan; Baumeister, Julia; Harms, Klaus; Koert, Ulrich
European Journal of Organic Chemistry, 2013 , # 4 p. 662 - 665
反应条件
Ambient temperaturephase-transfer conditions; Title compound not separated from byproducts;
参考文献
Singh, Harjit; Kumar, Subodh
Journal of Chemical Research, Miniprint, 1987 , # 12 p. 3201 - 3213
