beta-咔啉-3-羧酸叔丁酯合成路线 （共 8 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene
T=80 - 85°C; 18 h;
参考文献
Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M.
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368
反应条件
palladium diacetate; potassium carbonate; [(t-Bu)3PH]BF4 in N,N-dimethyl acetamide
T=120°C; Heck reaction; 16 h; Inert atmosphereSealed vessel; regioselective reaction;
参考文献
Namjoshi, Ojas A.; Gryboski, Angelica; Fonseca, German O.; Van Linn, Michael L.; Wang, Zhi-Jian; Deschamps, Jeffrey R.; Cook, James M.
Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4721 - 4727
反应条件
1: 85 percent / H2SO4 / Heating
2: 80 percent / MnO2 / benzene / Heating
3: 90 percent / NaOH / H2O / Heating
4: dimethylformamide / 2 h / 20 °C
5: 70 percent / DBU / 18 h / 80 - 85 °C
View Scheme
参考文献
Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M.
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368
反应条件
1: dimethylformamide / 2 h / 20 °C
2: 70 percent / DBU / 18 h / 80 - 85 °C
View Scheme
参考文献
Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M.
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368
反应条件
1: 95 percent / H2O / 37 °C
2: 85 percent / H2SO4 / Heating
3: 80 percent / MnO2 / benzene / Heating
4: 90 percent / NaOH / H2O / Heating
5: dimethylformamide / 2 h / 20 °C
6: 70 percent / DBU / 18 h / 80 - 85 °C
View Scheme
参考文献
Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M.
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368
反应条件
1: 90 percent / NaOH / H2O / Heating
2: dimethylformamide / 2 h / 20 °C
3: 70 percent / DBU / 18 h / 80 - 85 °C
View Scheme
参考文献
Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M.
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368
反应条件
1: 80 percent / MnO2 / benzene / Heating
2: 90 percent / NaOH / H2O / Heating
3: dimethylformamide / 2 h / 20 °C
4: 70 percent / DBU / 18 h / 80 - 85 °C
View Scheme
参考文献
Yin, Wenyuan; Sarma, P. V. V. Srirama; Ma, Jun; Han, Dongmei; Chen, Jessica L.; Cook, James M.
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6363 - 6368
参考文献
Hagen, Timothy J.; Guzman, Filadelfo; Schultz, Christopher; Cook, James M.; Skolnick, Phil; Shannon, Harlan E.
Heterocycles, 1986 , vol. 24, # 10 p. 2845 - 2855
