2,4-二氯-6-甲氧基苯胺合成路线 （共 8 条）
反应条件
sulfuric acid in acetic acid T=20°C; Acetylation; 2 h;
参考文献
Waterhouse, Ian
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1075 - 1083
反应条件
1: NaNO2; H2SO4 / H2O / 2 h / Heating
2: K2CO3 / dimethylformamide / 1 h / 60 °C
3: Sn / HCl / 1 h / Heating
View Scheme
参考文献
Waterhouse, Ian
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1075 - 1083
反应条件
sodium dithionite in ethanol
2 h; Heating;
参考文献
Waller, Stephen C.; He, You Ai; Harlow, Greg R.; He, You Qun; Mash, Eugene A.; Halpert, James R.
Chemical Research in Toxicology, 1999 , vol. 12, # 8 p. 690 - 699
反应条件
1: HNO3; H2SO4 / CH2Cl2 / 18 h / 20 °C
2: 19 percent / Na2S2O4 / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Waller, Stephen C.; He, You Ai; Harlow, Greg R.; He, You Qun; Mash, Eugene A.; Halpert, James R.
Chemical Research in Toxicology, 1999 , vol. 12, # 8 p. 690 - 699
反应条件
1: 3,5-Dichlorophenol With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: With aniline; sodium hydroxide in water
3: dimethyl sulfate Further stages;
参考文献
Joshi; Vyas; Duffel; Parkin; Lehmler
Synthesis, 2011 , # 7 p. 1045 - 1054
反应条件
hydrogenchloride; chlorine in tetrachloromethane; ethanol
ice-bath;
参考文献
Pews; Hunter; Wehrmeyer
Tetrahedron, 1993 , vol. 49, # 22 p. 4809 - 4820
反应条件
tin in hydrogenchloride
Reduction; 1 h; Heating;
参考文献
Waterhouse, Ian
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1075 - 1083
反应条件
1: With sulfuric acid; nitric acid in dichloromethane
18 h;
2: With sodium dithionite in ethanol; water
14 h; Heating;
参考文献
Joshi; Vyas; Duffel; Parkin; Lehmler
Synthesis, 2011 , # 7 p. 1045 - 1054
