7-氯吡啶并[2,3-d]嘧啶-2,4-二醇合成路线 （共 7 条）
反应条件
oxalyl dichloride in toluene T=115°C; 20 h;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2007/60404 A1, 2007 ;
Location in patent: Page/Page column 57-59 ;
WO 2007/060404 A1
参考文献
ASTRAZENECA AB
Patent: US2009/99174 A1, 2009 ;
反应条件
1: ammonia / 130 °C / 13501.4 Torr 2: thionyl chloride / tetrahydrofuran / 20 °C 3: ammonia / tetrahydrofuran / 20 °C 4: toluene / 115 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 5 p. 1212 - 1216
反应条件
1: thionyl chloride / tetrahydrofuran / 20 °C 2: ammonia / tetrahydrofuran / 20 °C 3: toluene / 115 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 5 p. 1212 - 1216
反应条件
1: With N-ethyl-N,N-diisopropylamine in toluene T=70°C; 0.5 h; 2: With trichlorophosphate in toluene T=20 - 100°C; 2.5 h;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2008/23161 A1, 2008 ;
Location in patent: Page/Page column 101 ;
WO 2008/023161 A1
反应条件
1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C View Scheme
参考文献
Pike, Kurt G.; Malagu, Karine; Hummersone, Marc G.; Menear, Keith A.; Duggan, Heather M.E.; Gomez, Sylvie; Martin, Niall M.B.; Ruston, Linette; Pass, Sarah L.; Pass, Martin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1212 - 1216
反应条件
1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 70 °C
View Scheme
参考文献
Pike, Kurt G.; Malagu, Karine; Hummersone, Marc G.; Menear, Keith A.; Duggan, Heather M.E.; Gomez, Sylvie; Martin, Niall M.B.; Ruston, Linette; Pass, Sarah L.; Pass, Martin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1212 - 1216
