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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
8-羟基辛酸乙酯
合成路线
（共 18 条）
4286-55-9
6-溴正己醇
→
反应条件
93892-06-9
8-羟基辛酸乙酯
反应条件
1: 75 percent / conc.HCl / 5 h / Ambient temperature 2: 63 percent / dimethylsulfoxide / 12 h / Ambient temperature 3: 92 percent / KOAc / dimethylsulfoxide / 6 h / 80 °C 4: 85 percent / p-TsOH / ethanol / 12 h / Ambient temperature View Scheme
参考文献
Bhide, K. S.; Sharma, G. V. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1081 - 1083
25542-62-5
6-溴己酸乙酯
→
反应条件
93892-06-9
8-羟基辛酸乙酯
反应条件
1: 66 percent / LAH / diethyl ether / 3 h / -78 °C 2: 75 percent / conc.HCl / 5 h / Ambient temperature 3: 63 percent / dimethylsulfoxide / 12 h / Ambient temperature 4: 92 percent / KOAc / dimethylsulfoxide / 6 h / 80 °C 5: 85 percent / p-TsOH / ethanol / 12 h / Ambient temperature View Scheme
参考文献
Bhide, K. S.; Sharma, G. V. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1081 - 1083
57221-90-6
→
反应条件
93892-06-9
8-羟基辛酸乙酯
反应条件
1: 92 percent / KOAc / dimethylsulfoxide / 6 h / 80 °C 2: 85 percent / p-TsOH / ethanol / 12 h / Ambient temperature View Scheme
参考文献
Bhide, K. S.; Sharma, G. V. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1081 - 1083
629-41-4
1,8-辛二醇
→
反应条件
93892-06-9
8-羟基辛酸乙酯
反应条件
1.1: pyridinium p-toluenesulfonate / chloroform / 18 h / 20 °C / |Inert atmosphere 2.1: oxalyl dichloride; dimethyl sulfoxide / chloroform / 2 h / -55 °C 2.2: 0.75 h / -55 - 0 °C 3.1: sodium dihydrogen phosphate dihydrate / water; acetonitrile / 0.17 h / -15 °C 3.2: 0.08 h 3.3: 1 h 4.1: sulfuric acid / 15 h / 60 °C View Scheme
参考文献
aRigen Pharmaceuticals, Inc.; SAIMOTO, Hiroyuki; KITA, Kiyoshi; YABU, Yoshisada; YAMAMOTO, Masaichi
Patent: EP2636663 A1, 2013 ;
51326-52-4
→
反应条件
93892-06-9
8-羟基辛酸乙酯
反应条件
1.1: oxalyl dichloride; dimethyl sulfoxide / chloroform / 2 h / -55 °C 1.2: 0.75 h / -55 - 0 °C 2.1: sodium dihydrogen phosphate dihydrate / water; acetonitrile / 0.17 h / -15 °C 2.2: 0.08 h 2.3: 1 h 3.1: sulfuric acid / 15 h / 60 °C View Scheme
参考文献
aRigen Pharmaceuticals, Inc.; SAIMOTO, Hiroyuki; KITA, Kiyoshi; YABU, Yoshisada; YAMAMOTO, Masaichi
Patent: EP2636663 A1, 2013 ;
5698-29-3
氧杂环壬烷-2-酮
+
64-17-5
乙醇
→
反应条件
93892-06-9
8-羟基辛酸乙酯
反应条件
sulfuric acid 6 h; Reflux;
参考文献
Kudo, Fumitaka; Asou, Yusaku; Watanabe, Moe; Kitayama, Takashi; Eguchi, Tadashi
Synlett, 2012 , vol. 23, # 12 p. 1843 - 1846
93892-06-9
8-羟基辛酸乙酯
→
反应条件
793-32-8
反应条件
VinP4 polyketide synthase thioesterase domain in dimethyl sulfoxide T=28°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Kudo, Fumitaka; Asou, Yusaku; Watanabe, Moe; Kitayama, Takashi; Eguchi, Tadashi
Synlett, 2012 , vol. 23, # 12 p. 1843 - 1846
93892-06-9
8-羟基辛酸乙酯
→
反应条件
5698-29-3
氧杂环壬烷-2-酮
反应条件
zirconium oxide in toluene T=275°C;
参考文献
Kuno, Hideyuki; Shibagaki, Makoto; Takahashi, Kyoko; Honda, Ichiro; Matsushita, Hajime
Chemistry Letters, 1992 , # 4 p. 571 - 574
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