2-氰基-6-羟基苯并噻唑合成路线 （共 26 条）
反应条件
1.1: dichloromethane / 1 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / -5 °C 3.1: copper(l) iodide; tetrabutylammomium bromide; palladium dichloride / dimethyl sulfoxide; N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 4.1: pyridine hydrochloride / 1 h / 180 °C / Neat (no solvent); Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 18 p. 7604 - 7607
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / -5 °C 2: copper(l) iodide; tetrabutylammomium bromide; palladium dichloride / dimethyl sulfoxide; N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 3: pyridine hydrochloride / 1 h / 180 °C / Neat (no solvent); Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 18 p. 7604 - 7607
反应条件
1: 1.) AcOH, aq. H2SO4, aq. NaNO2, 2.) NaHCO3 / 1.) 1 h, 2.) water, 30 min 2: 81 percent / pyridinium chloride / 0.75 h / 200 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 392 - 395
反应条件
dihydrogen peroxide in aq. buffer Kinetics;
参考文献
Journal of the American Chemical Society, , vol. 135, # 5 p. 1783 - 1795
参考文献
White,E.H. et al.
Journal of the American Chemical Society, 1963 , vol. 85, p. 337 - 343
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White,E.H. et al.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2344 - 2348
参考文献
Suzuki,N. et al.
Tetrahedron, 1972 , vol. 28, p. 4065 - 4074
反应条件
1: 57 percent / M sodium hydroxide / acetone 2: 1.) potassium carbonate, 2.) ammonia / 1.) water, methanol, chloroform, 15 min, 2.) methanol, 3 h View Scheme
参考文献
Amess, Robert; Baggett, Neil; Darby, Paul R.; Goode, Anthony R.; Vickers, Ernest E.
Carbohydrate Research, 1990 , vol. 205, # 1 p. 225 - 233
参考文献
White,E.H. et al.
Journal of the American Chemical Society, 1963 , vol. 85, p. 337 - 343
参考文献
Meroni, Giuseppe; Ciana, Paolo; Maggi, Adriana; Santaniello, Enzo
Synlett, 2009 , # 16 p. 2682 - 2684
反应条件
potassium carbonate in methanol; water 0.333333 h; Inert atmosphere;
参考文献
McCutcheon, David C.; Paley, Miranda A.; Steinhardt, Rachel C.; Prescher, Jennifer A.
Journal of the American Chemical Society, 2012 , vol. 134, # 18 p. 7604 - 7607
