1: potassium carbonate; triphenylphosphine; palladium diacetate / water; ethylene glycol dimethyl ether; tetrahydrofuran / 8 h / 70 °C / |Inert atmosphere 2: lithium diethylamide / ethylene glycol dimethyl ether / 2.42 h / -45 °C / |Inert atmosphere 3: bromine / ethylene glycol dimethyl ether / 4.5 h / 10 - 45 °C / |Inert atmosphere 4: sodium carbonate / water; ethylene glycol dimethyl ether / 6 h / 55 °C / |Inert atmosphere View Scheme

1: potassium carbonate; triphenylphosphine; palladium diacetate / water; ethylene glycol dimethyl ether; tetrahydrofuran / 8 h / 70 °C / |Inert atmosphere 2: lithium diethylamide / ethylene glycol dimethyl ether / 2.42 h / -45 °C / |Inert atmosphere View Scheme