PF 562271 苯磺酸盐; N-甲基-N-[3-[[[2-[(2-氧代-2,3-二氢-1H-吲哚-5-基)氨基]-5-三氟甲基嘧啶-4-基]氨基]甲基]吡啶-2-基]甲磺酰胺苯磺酸盐合成路线 （共 4 条）
反应条件
in ethanol; water
T=70°C; Industry scale; Product distribution / selectivity;
参考文献
Pfizer Inc.
Patent: US2011/33441 A1, 2011 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h
1.2: 35 °C / Industry scale
2.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale
3.1: ethanol; water / 70 °C / Industry scale
View Scheme
参考文献
Pfizer Inc.
Patent: US2011/33441 A1, 2011 ;
反应条件
1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / water / 22 h / 20 - 100 °C / Industry scale
2.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h
2.2: 35 °C / Industry scale
3.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale
4.1: ethanol; water / 70 °C / Industry scale
View Scheme
参考文献
Pfizer Inc.
Patent: US2011/33441 A1, 2011 ;
反应条件
1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale
2: ethanol; water / 70 °C / Industry scale
View Scheme
参考文献
Pfizer Inc.
Patent: US2011/33441 A1, 2011 ;
