N-(3-(氨基甲基)吡啶-2-基)-N-甲基甲烷磺酰胺合成路线 (共 2 条)
反应条件
ammonia; hydrogen; palladium 10 on activated carbon in methanol; water
P=2585.81 Torr;
参考文献
CEPHALON, INC.; CURRY, Matthew A.; DORSEY, Bruce D.; DUGAN, Benjamin J.; GINGRICH, Diane E.; MESAROS, Eugen F.; MILKIEWICZ, Karen L.
Patent: WO2010/141796 A2, 2010 ;
Location in patent: Page/Page column 215 ;
反应条件
1: With trifluoroacetic acid in dichloromethane
0.333333 h;
2: With Amberlyst A-21 in dichloromethane
0.5 h;
参考文献
THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2008/115369 A2, 2008 ;
Location in patent: Page/Page column 99-100 ;
WO 2008/115369 A2