(2-氯-3,4-二甲氧基苯基)甲醇合成路线 （共 14 条）
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 4: 19 percent / 2.5 h / Heating 5: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 4: 19 percent / 2.5 h / Heating 5: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C 6: 95 percent / BBr3 / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 4: 19 percent / 2.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 84 percent / SOCl2 / 24 h / Heating 2: 67 percent / 18-crown-6 / acetonitrile / 168 h / Heating 3: 51 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 4: Me3SiI / CHCl3; tetrahydrothiophene 1,1-dioxide / 72 h / 50 °C View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
sodium tetrahydroborate in ethanol
T=25°C; 1 h;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 90 percent / Cl2
2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating
2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 1.) N,N,N'-trimethylethylenediamine, n-BuLi, 2.) hexachloroethane / 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: 97 percent / 12N aq. HCl
2: 96 percent / dimethylsulfoxide / 1.25 h
3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
4: K2CO3 / dimethylformamide / 2 h / 110 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
