(2-氯-3,4-二甲氧基苯基)甲醇合成路线 （共 14 条）
反应条件
1: 97 percent / 12N aq. HCl
2: 96 percent / dimethylsulfoxide / 1.25 h
View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: 97 percent / 12N aq. HCl
2: 96 percent / dimethylsulfoxide / 1.25 h
3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating
4: 37 percent / 2.5 h / Heating
5: TFA, 36 N aq. H2SO4 / 3.5 h / 25 °C
6: BBr3 / CH2Cl2 / 3 h / 25 °C
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
With phosphorus tribromide in diethyl ether T=20°C; 2 h; Show Experimental Procedure
参考文献
SMITHKLINE BEECHAM CORPORATION Patent: WO2007/65093 A2, 2007 ; Location in patent: Page/Page column 122 ;
