2-氯-1-(氯甲基)-3,4-二甲氧基苯合成路线 （共 17 条）
反应条件
1: hexamethylenetetramine; CHCl3 / und Erhitzen des Reaktionsprodukts mit wss.Essigsaeure 2: aqueous HBr View Scheme
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 3: 19 percent / 2.5 h / Heating 4: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
chloroform; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane und Erhitzen des Reaktionsprodukts mit wss.Essigsaeure;
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 3: 19 percent / 2.5 h / Heating 4: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C 5: 95 percent / BBr3 / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 3: 19 percent / 2.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 67 percent / 18-crown-6 / acetonitrile / 168 h / Heating 2: 51 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 3: Me3SiI / CHCl3; tetrahydrothiophene 1,1-dioxide / 72 h / 50 °C View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
2: 97 percent / 12N aq. HCl
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
