(2R,3s)-rel-2,3-双(4-氯苯基)-2,3-丁二胺合成路线 （共 3 条）
反应条件
1: With lithium aluminium tetrahydride; titanium(III) chloride; ammonia in tetrahydrofuran T=-15 - 20°C; Heating / reflux; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C; Acidic aqueous solution; 3: With sodium hydroxide in water Alkaline aqueous solution;
参考文献
US2007/129416 A1, ;
Page/Page column 12/2 ;
参考文献
US2014/148443 A1, ;
Page/Page column ;
反应条件
trimethylaluminum in toluene T=20°C; 2.5 h; Reflux;
参考文献
Vu, Binh; Wovkulich, Peter; Pizzolato, Giacomo; Lovey, Allen; Ding, Qingjie; Jiang, Nan; Liu, Jin-Jun; Zhao, Chunlin; Glenn, Kelli; Wen, Yang; Tovar, Christian; Packman, Kathryn; Vassilev, Lyubomir; Graves, Bradford
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 5 p. 466 - 469
