2-氰基-3-乙氧基丙烯酸乙酯合成路线 （共 100 条）
反应条件
acetic anhydride T=150 - 160°C; 5 h;
参考文献
Chen, Li; Chen, Shaoqing; Michoud, Christophe
Patent: US2006/4046 A1, 2006 ;
Location in patent: Page/Page column 35 ;
US 20060004046 A1
反应条件
zinc; benzene anfangs unter Kuehlung dann bei Siedetemperatur;
参考文献
Journal of the American Chemical Society, , vol. 69, p. 2234
参考文献
Synthesis, , p. 312 - 314
反应条件
in ethanol 24 h; RefluxInert atmosphere;
参考文献
Genentech, Inc.
Patent: US2012/22043 A1, 2012 ;
Location in patent: Page/Page column 94-95 ;
US 20120022043 A1
反应条件
sodium acetate; acetic acid in water 16 h; heated on a steam bath;
参考文献
Beck, James R.; Gajewski, Robert P.; Lynch, Michael P.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 267 - 270
反应条件
1: ethanol / Heating 2: isoamyl nitrite / tetrahydrofuran View Scheme
参考文献
Ishibuchi, Seigo; Morimoto, Hiroshi; Oe, Takanori; Ikebe, Tsuguo; Inoue, Hiroyoshi; Fukunari, Atsushi; Kamezawa, Miho; Yamada, Ichimaro; Naka, Yoichi
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 7 p. 879 - 882
参考文献
ShionogiandCo., Ltd.
Patent: EP2163543 A1, 2010 ;
Location in patent: Page/Page column 102 ;
EP 2163543 A1
参考文献
Ferring B.V.
Patent: EP1512687 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium sulfate in ethanol
参考文献
Eli Lilly and Company
Patent: US4620865 A1, 1986 ;
反应条件
in ethanol 5 h; Reflux;
参考文献
Danagulyan; Boyakhchyan; Panosyan
Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 3 p. 321 - 331
