2-氰基-3-乙氧基丙烯酸乙酯合成路线 （共 100 条）
反应条件
2: 87 percent / acetic acid / Heating View Scheme
参考文献
Svetlik, Jan
Heterocycles, 1984 , vol. 22, # 11 p. 2513 - 2516
反应条件
triethylamine in ethanol 7 h;
参考文献
Coppo, Frank T.; Fawzi, Maged M.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1693 - 1697
反应条件
sodium methylate in methanol T=20°C; 48 h; Reflux;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.
Patent: WO2013/158746 A1, 2013 ;
Location in patent: Page/Page column 88; 89 ;
反应条件
sodium methylate in methanol 48 h; Reflux;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
Location in patent: Page/Page column 103-104 ;
反应条件
in methanol T=45°C; 25 h; RefluxLarge scale reaction;
参考文献
Kamath, Vivekanand P.; Juarez-Brambila, Jesus J.; Morris, Christopher B.; Winslow, Christopher D.; Morris Jr., Philip E.
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 928 - 932
反应条件
sodium methylate 3 h; Heating;
参考文献
Elliott; Montgomery; Walsh
Tetrahedron Letters, 1996 , vol. 37, # 25 p. 4339 - 4340
参考文献
American Cyanamid Company
Patent: US6002008 A1, 1999 ;
US 6002008 A
反应条件
in Dowther T=140°C; 19 h; Heating / reflux;
参考文献
Wyeth Holdings Corporation
Patent: EP1117659 B1, 2003 ;
Location in patent: Page 51 ;
反应条件
sodium acetate in water; N,N-dimethyl-formamide
参考文献
Orvieto, Federica; Branca, Danila; Giomini, Claudia; Jones, Philip; Koch, Uwe; Ontoria, Jesus M.; Palumbi, Maria Cecilia; Rowley, Michael; Toniatti, Carlo; Muraglia, Ester
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4196 - 4200
反应条件
T=100°C; 0.5 h; Neat (no solvent);
参考文献
Wyeth Holdings Corporation
Patent: EP973746 B1, 2003 ;
Location in patent: Page/Page column 37 ;
EP 0973746 B1
