2-氰基-3-乙氧基丙烯酸乙酯合成路线

参考文献

CHROMA THERAPEUTICS LTD.
Patent: WO2008/53136 A1, 2008 ;
Location in patent: Page/Page column 35-36 ;
WO 2008/053136 A1

94-05-32-氰基-3-乙氧基丙烯酸乙酯

138907-68-35-氨基-1-(4-氟苯)吡唑-4-羧酸乙酯

参考文献

Pfizer Inc.
Patent: US5064851 A1, 1991 ;
US 5064851 A

371-14-24-氟苯肼+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

138907-68-35-氨基-1-(4-氟苯)吡唑-4-羧酸乙酯

参考文献

Mitsubishi Pharma Corporation
Patent: EP1176140 A1, 2002 ;
Location in patent: Page 45 - 46 ;

51859-98-42-氟苄基肼+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

137278-69-4

参考文献

Gatta, Franco; Pomponi, Massimo; Marta, Maurizio
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1301 - 1308

94-05-32-氰基-3-乙氧基丙烯酸乙酯

16459-33-95-氨基-1-（2-硝基苯基）-1H-吡唑-4-羧酸乙酯

参考文献

Costanzo; Bruni; Guerrini; Selleri; Malmberg Aiello; Lamberti
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1499 - 1505

138907-69-45-氨基-1-(2,5-二氟苯基)吡唑-4-甲酸乙酯

参考文献

Wurz, Ryan P.; Pettus, Liping H.; Xu, Shimin; Henkle, Bradley; Sherman, Lisa; Plant, Matthew; Miner, Kent; McBride, Helen; Wong, Lu Min; Saris, Christiaan J.M.; Lee, Matthew R.; Chmait, Samer; Mohr, Christopher; Hsieh, Faye; Tasker, Andrew S.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4724 - 4728

16800-68-3N-乙酰基-3-吲哚啉酮+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

136429-63-5

参考文献

Merour, J.Y.; Piroelle, S.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 8 p. 1869 - 1873

94-05-32-氰基-3-乙氧基丙烯酸乙酯

1260243-04-65-氨基-1H-吡唑-4羧酸乙酯

参考文献

US2012/277224 A1, ;

Page/Page column 18 ;
US 20120277224 A1

70629-60-6异丙基肼二盐酸盐+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

1759-24-6

参考文献

Pfizer Inc
Patent: US2012/108619 A1, 2012 ;
Location in patent: Page/Page column 19 ;

2257-52-5异丙基肼+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

1759-24-6

参考文献

GLAX0SMITHKLINE LLC; BURGESS, Joelle, Lorraine; JOHNSON, Neil, W.; KNIGHT, Steven, David; LAFRANCE, Louis, Vincent, III; MILLER, William, H.; NEWLANDER, Kenneth, Allen; ROMERIL, Stuart, Paul; ROUSE, Meagan, B.; SUAREZ, Dominic; TIAN, Xinrong; VERMA, Sharad, Kumar
Patent: WO2013/39988 A1, 2013 ;
Location in patent: Page/Page column 44-45 ;