1: 93 percent / Cs2CO3 / acetonitrile; H2O / 2.5 h / 30 - 35 °C 2: aq. phosphate buffer, Triton X-100 / 37 °C / pH 7, lipase PS-800 3: HOBT, DCC / various solvent(s) / 1.5 h / 48 - 50 °C View Scheme
参考文献
Cvetovich, Raymond J.; Chartrain, Michel; Hartner Jr., Frederick W.; Roberge, Christopher; Amato, Joseph S.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6575 - 6580
1: 89.8 percent / Et3N / CH2Cl2 / 1.5 h / Heating 2: 60.5 percent / H2 / 10percent Pd-C / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Neubert, M. E.; Keast, S. S.; Ezenyilimba, M. C.; Greer, P. B.; Jones, W. C.; et al.
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1993 , vol. 237, p. 47 - 68
