1,4-环己二甲酸二甲酯合成路线 （共 39 条）
反应条件
1: sulfuric acid / 16 h / Reflux 2: m-xylene / 48 h / 151 - 168 °C / 13446.2 Torr 3: hydrogen / palladium on activated charcoal / dichloromethane / 20 °C View Scheme
反应条件
1: m-xylene / 48 h / 151 - 168 °C / 13446.2 Torr 2: hydrogen / palladium on activated charcoal / dichloromethane / 20 °C View Scheme
反应条件
1: iodine / acetonitrile / 25 h / Reflux; Ambient light 2: m-xylene / 48 h / 151 - 168 °C / 13446.2 Torr 3: hydrogen / palladium on activated charcoal / dichloromethane / 20 °C View Scheme
反应条件
1: iodine / acetonitrile / 15 h / Reflux; Ambient light 2: m-xylene / 48 h / 151 - 168 °C / 13446.2 Torr 3: hydrogen / palladium on activated charcoal / dichloromethane / 20 °C View Scheme
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1752 - 1761
反应条件
1: SOCl2 / Heating 2: CHCl3 View Scheme
参考文献
Journal of Physical Chemistry, , vol. 85, # 22 p. 3211 - 3215
参考文献
Journal of Physical Chemistry, , vol. 85, # 22 p. 3211 - 3215
反应条件
1: cyclohexane-1,4-dicarboxylic acid dimethyl ester With N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-67 - 0°C; 1 h; 2: 1-bromo-2-chloro-ethane in tetrahydrofuran; hexane T=-55 - 20°C; 1 h; 3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
ROYALTY, Susan Marie; BURNS, James Ford; SCICINSKI, Jan Jozef; FOGLESONG, Robert James; JAGDMANN, JR., Gunnar Erik; GRIFFIN, Kellee Renee; DYAKONOV, Tatyana; MIDDLEMISS, David
Patent: WO2006/12441 A1, 2006 ;
Location in patent: Page/Page column 32-33 ;
WO 2006/012441 A1
反应条件
1: cyclohexane-1,4-dicarboxylic acid dimethyl ester With N,N,N',N'-tetramethyl-urea; lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 1.16667 h; 2: 1-bromo-1-chloro ethane in tetrahydrofuran; hexane T=-78 - 25°C; 3: With hydrogenchloride in tetrahydrofuran; hexane; water 0.166667 h;
参考文献
Biogen, Inc.
Patent: US6649600 B1, 2003 ;
Location in patent: Page/Page column 51 ;
US 6649600 B1
反应条件
T=13°C; Isomerization; 2 h;
参考文献
Mikhaleva; Kuznetsova
Chemistry of Heterocyclic Compounds, 1999 , vol. 35, # 3 p. 310 - 315
