1,4-环己二甲酸二甲酯合成路线 （共 39 条）
反应条件
water; Ba(OH)2 in methanol T=25°C; 12 h;
参考文献
MERCK SHARP and DOHME CORP.; BARR, Kenneth Jay; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; ZHANG, Dongshan
Patent: WO2014/28597 A2, 2014 ;
Location in patent: Page/Page column 54 ;
反应条件
sodium phosphate buffer; lipase from Candida rugosa 14 h; pH 7.2; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Koenigsberger, Kurt; Luna, Hector; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron Letters, 1996 , vol. 37, # 50 p. 9029 - 9032
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 0.5 h; 2: With water in tetrahydrofuran
参考文献
Zhang, Shaoyan; Fan, Guoli; Li, Feng
Green Chemistry, 2013 , vol. 15, # 9 p. 2389 - 2393
反应条件
hydrogen in methanol T=220°C; P=45004.5 Torr; Green chemistry;
参考文献
Zhang, Shaoyan; Fan, Guoli; Li, Feng
Green Chemistry, 2013 , vol. 15, # 9 p. 2389 - 2393
反应条件
1: 72 percent / LDA, HMPA / tetrahydrofuran / -78 deg C to RT 2: 50 percent / KOH / methanol; H2O / 24 h / 50 °C View Scheme
参考文献
KYORIN PHARMACEUTICAL CO., LTD.; MERCK SHARP and DOHME CORP.; FUKUDA, Yasumichi; KAELIN, David E. Jr.; SINGH, Sheo B.
Patent: WO2013/3383 A1, 2013 ;
反应条件
hydrogen; Raney nickel doped, 3wtpercent Re; Metalyste Alpha.(R). 9401 T=205 - 225°C; P=259341 Torr; Product distribution / selectivity;
参考文献
US6919489 B1, ;
Page column 12 ;
反应条件
hydrogen in methanol T=220°C; P=45004.5 Torr; Green chemistry;
参考文献
Green Chemistry, , vol. 15, # 9 p. 2389 - 2393
反应条件
1: water; Ba(OH)2 / methanol / 12 h / 25 °C 2: BH3*SMe2 / tetrahydrofuran / 3 h / 15 °C View Scheme
参考文献
Koenigsberger, Kurt; Luna, Hector; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron Letters, 1996 , vol. 37, # 50 p. 9029 - 9032
