3,5-双(氯甲基)吡啶盐酸盐合成路线 (共 4 条)
反应条件
1: phenyl-magnesium bromide With Et2AlBr in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With titanium(IV) isopropylate; (S)-(minus;)-1,1'-bi-2-naphthol in toluene
T=0°C; 0.5 h; Inert atmosphere;
3: (3-methoxyphenyl)acetoaldehyde Further stages;
参考文献
Zhou, Shuangliu; Wu, Kuo-Hui; Chen, Chien-An; Gau, Han-Mou
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3500 - 3505
反应条件
1: bromobenzene With magnesium; ethylene dibromide in tetrahydrofuran
T=20°C; 2.16667 h; Inert atmosphere;
2: (3-methoxyphenyl)acetoaldehyde in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Bess, Elizabeth N.; Sigman, Matthew S.
Organic Letters, 2013 , vol. 15, # 3 p. 646 - 649
反应条件
in diethyl ether
T=0°C; competition reaction with bezophenone and 3-methoxy-benzophenone, relative velocity constant;
参考文献
Yamataka, Hiroshi; Fujimura, Naoya; Kawafuji, Yukie; Hanafusa, Terukiyo
Journal of the American Chemical Society, 1987 , vol. 109, # 14 p. 4305 - 4308
参考文献
Novak; Protiva
Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 3966,3974