1-(4-甲氧基-苯基)-1-苯基-乙醇合成路线 （共 19 条）
反应条件
1: H2SO4; acetic acid 2: 70 percent / gold(I) chloride; tert-butyl hydroperoxide; neocuproine / H2O; 2-methyl-propan-2-ol / 3 h / 90 °C View Scheme
参考文献
Xing, Dong; Guan, Bingtao; Cai, Guixin; Fang, Zhao; Yang, Liping; Shi, Zhangjie
Organic Letters, 2006 , vol. 8, # 4 p. 693 - 696
反应条件
1: 4-methoxyphenyl magnesium bromide With Et2AlBr in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With titanium(IV) isopropylate; (S)-(minus;)-1,1'-bi-2-naphthol in toluene
T=0°C; 0.5 h; Inert atmosphere;
3: acetophenone Further stages;
参考文献
Zhou, Shuangliu; Wu, Kuo-Hui; Chen, Chien-An; Gau, Han-Mou
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3500 - 3505
反应条件
1: phenyl-magnesium bromide With Et2AlBr in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With titanium(IV) isopropylate; (S)-(minus;)-1,1'-bi-2-naphthol in toluene
T=0°C; 0.5 h; Inert atmosphere;
3: 1-(4-methoxyphenyl)ethanone Further stages;
参考文献
Zhou, Shuangliu; Wu, Kuo-Hui; Chen, Chien-An; Gau, Han-Mou
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3500 - 3505
反应条件
2-hydroxy-1,3-isoindolinedione; 2,2'-azo-bisisobutyronitrile; oxygen; triphenylphosphine in acetonitrile
T=75°C; P=760.051 Torr; 1 h;
参考文献
Nakamura, Ryota; Obora, Yasushi; Ishii, Yasutaka
Chemical Communications, 2008 , # 29 p. 3417 - 3419
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in toluene
T=80°C; 5 h; Inert atmosphere;
参考文献
Berini, Christophe; Navarro, Oscar
Chemical Communications, 2012 , vol. 48, # 10 p. 1538 - 1540
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in diethyl ether
Grignard reaction;
2: acetophenone in diethyl ether
2 h; Heating; Further stages.;
参考文献
Van Walree, Cornelis A.; Kaats-Richters, Veronica E. M.; Veen, Sandra J.; Wieczorek, Birgit; Van Der Wiel, Johanna H.; Van Der Wiel, Bas C.
European Journal of Organic Chemistry, 2004 , # 14 p. 3046 - 3056
反应条件
bis(1,5-cyclooctadiene)nickel (0); cesium fluoride; SIDip*HCl in toluene
T=120°C; Inert atmosphere;
参考文献
Bouffard, Jean; Itami, Kenichiro
Organic Letters, 2009 , vol. 11, # 19 p. 4410 - 4413
反应条件
1: bromobenzene With magnesium; ethylene dibromide in tetrahydrofuran
T=20°C; 2.16667 h; Inert atmosphere;
2: 1-(4-methoxyphenyl)ethanone in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Bess, Elizabeth N.; Sigman, Matthew S.
Organic Letters, 2013 , vol. 15, # 3 p. 646 - 649
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; cesium fluoride in toluene
T=80°C; Inert atmosphere;
参考文献
Bouffard, Jean; Itami, Kenichiro
Organic Letters, 2009 , vol. 11, # 19 p. 4410 - 4413
参考文献
Hurd; Webb
Journal of the American Chemical Society, 1927 , vol. 49, p. 557
